General Information of Drug (ID: DR5168)
Drug Name
Phenmetrazine
Synonyms
Cafilon; Defenmetrazin; Dexphenmetrazine; Fenmetrazin; Fenmetrazina; Oxazimedrine; Phenmetraline; Phenmetrazin; Phenmetrazinum; Preludin hydrochloride; A 66; Psychamine A 66; Defenmetrazin (TN); Fenmetrazin (TN); Fenmetrazina [INN-Spanish]; Oxazimedrine (TN); Phenmetraline (TN); Phenmetrazine [INN:BAN]; Phenmetrazinum [INN-Latin]; Dl-2-Phenyl-3-methyltetrahydro-1,4-oxazine; 2-Fenyl-3-methylmorfolin; 2-Fenyl-3-methylmorfolin [Czech]; 2-Phenyl-3-methylmorpholine; 3-Methyl-2-phenylmorpholine; 3-Methyl-2-phenyltetrahydro-2H-1,4-oxazine
Indication Obesity [ICD11: 5B80-5B81] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 177.24 Topological Polar Surface Area 21.3
Heavy Atom Count 13 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
4762
ChEBI ID
CHEBI:8067
CAS Number
134-49-6
TTD Drug ID
D0M2MC
Formula
C11H15NO
Canonical SMILES
CC1C(OCCN1)C2=CC=CC=C2
InChI
InChI=1S/C11H15NO/c1-9-11(13-8-7-12-9)10-5-3-2-4-6-10/h2-6,9,11-12H,7-8H2,1H3
InChIKey
OOBHFESNSZDWIU-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
3-oxophenmetrazine DM014990
21789
Other reaction - Lactam formation 1 [3]
4'-Hydroxyphenmetrazine DM015247
191340
Oxidation - Aromatic Hydroxylation 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR010869 Phenmetrazine 3-oxophenmetrazine Other reaction - Lactam formation Unclear [3]
MR010870 Phenmetrazine 4'-Hydroxyphenmetrazine Oxidation - Aromatic Hydroxylation Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[2]
Cytochrome P450 3A (CYP3A) DMEN065 . Not Available Not Available [2]
References
1 Drug information of Phenmetrazine, 2008. eduDrugs.
2 DrugBank(Pharmacology-Metabolism):Phenmetrazine
3 Comparative metabolism of the amphetamine drugs of dependence in man and monkeys

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