Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5194)
Drug Name
Pindolol
Synonyms
Betapindol; Blocklin; Calvisken; Carvisken; Decreten; Durapindol; Pectobloc; Pinbetol; Pindololum; Prindolol; Prinodolol; Pynastin; Visken; Blockin L; Blocklin L; LB 46; LB46; P 0778; Betapindol (TN); Blockin L (TN); Blocklin L (TN); Blocklin-L; Calvisken (TN); Cardilate (TN); Carvisken (TN); DL-LB 46; DL-Pindolol; Decreten (TN); Durapindol (TN); Glauco-Viskin; Glauco-visken; LB-46; P-6820; Pectobloc (TN); Pinbetol (TN); Pindololum [INN-Latin]; Prindolol (TN); Pynastin (TN); Visken (TN); Blocklin-L (TN); Glauco-Visken (TN); Pindolol (JP15/USP/INN); Pindolol [USAN:INN:BAN:JAN]; DL-4-[2-Hydroxy-3-(isopropylamino)propoxy]indole; (+-)-Pindolol; (1)-1-(1H-Indol-4-yloxy)-3-(isopropylamino)propan-2-ol; 1-((1-Methylethyl)amino)-3-(4-indolyloxy)-2-propanol; 1-(1H-Indol-4-yloxy)-3-((1-methylethyl)amino)-2-propanol; 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol; 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol; 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol; 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)-propan-2-ol; 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol; 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]propan-2-ol; 1-(1H-indol-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol; 1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol; 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole; 4-(3-(Isopropylamino)-2-hydroxypropoxy)indole
Indication Hypertension [ICD11: BA00-BA04] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 248.32 Topological Polar Surface Area 57.3
Heavy Atom Count 18 Rotatable Bond Count 6
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
4828
ChEBI ID
CHEBI:8214
CAS Number
13523-86-9
TTD Drug ID
D0F2PO
Formula
C14H20N2O2
Canonical SMILES
CC(C)NCC(COC1=CC=CC2=C1C=CN2)O
InChI
InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
InChIKey
JZQKKSLKJUAGIC-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
3-Hydroxy Pindolol DM016984 N. A. Unclear - Unclear 1 [3]
Isopr opylamine DM014900
6363
Unclear - Unclear 1 [4]
Pindolol Glucuronide DM016414
91810527
Unclear - Unclear 1 [4]
Pindolol metabolite DM016416
91810570
Unclear - Unclear 1 [4]
Pindolol metabolite DM015819
13116553
Unclear - Unclear 1 [4]
Pindolol metabolite DM016314
71440701
Unclear - Unclear 1 [4]
Pindolol metabolite DM016413
91810526
Unclear - Unclear 1 [4]
Pindolol metabolite DM015827
13340511
Unclear - Unclear 1 [4]
Pindolol metabolite DM016989 N. A. Unclear - Unclear 1 [4]
Pindolol metabolite DM016988 N. A. Unclear - Unclear 1 [4]
Pindolol metabolite DM016825
156596470
Unclear - Unclear 1 [4]
Pindolol 3-glucuronide DM016985 N. A. Unclear - Unclear 2 [3]
Pindolol metabolite DM016987 N. A. Unclear - Unclear 2 [4]
Pindolol Sulfate DM016986 N. A. Unclear - Unclear 2 [3]
⏷ Show the Full List of 14  DM(s)
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR007878 Pindolol 3-Hydroxy Pindolol Unclear - Unclear Unclear [3]
MR007881 Pindolol Pindolol metabolite Unclear - Unclear Unclear [4]
MR007883 Pindolol Pindolol Glucuronide Unclear - Unclear Unclear [4]
MR007884 Pindolol Pindolol metabolite Unclear - Unclear Unclear [4]
MR007885 Pindolol Pindolol metabolite Unclear - Unclear Unclear [4]
MR007886 Pindolol Pindolol metabolite Unclear - Unclear Unclear [4]
MR007887 Pindolol Pindolol metabolite Unclear - Unclear Unclear [4]
MR007888 Pindolol Pindolol metabolite Unclear - Unclear Unclear [4]
MR007889 Pindolol Pindolol metabolite Unclear - Unclear Unclear [4]
MR007890 Pindolol Pindolol metabolite Unclear - Unclear Unclear [4]
MR007891 Pindolol Isopr opylamine Unclear - Unclear Unclear [4]
MR007879 3-Hydroxy Pindolol Pindolol 3-glucuronide Unclear - Unclear Unclear [3]
MR007880 3-Hydroxy Pindolol Pindolol Sulfate Unclear - Unclear Unclear [3]
MR007882 Pindolol metabolite Pindolol metabolite Unclear - Unclear Unclear [4]
⏷ Show the Full List of 14 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[2]
References
1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 91).
2 Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes. Biochem Pharmacol. 1992 Dec 1;44(11):2089-98.
3 DrugBank(Pharmacology-Metabolism):Pindolol
4 Pindolol: disposition and metabolism in rhesus monkeys after chronic treatment

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