Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5427)
Drug Name
Amtolmetin guacil
Synonyms Artromed; Atromed; Eufans; Amtolmetin guacyl; MED-15; ST-679
Indication Inflammation [ICD11: 1A00-CA43] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 420.5 Topological Polar Surface Area 86.6
Heavy Atom Count 31 Rotatable Bond Count 9
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
65655
ChEBI ID
CHEBI:135678
CAS Number
87344-06-7
TTD Drug ID
D0S5RZ
Formula
C24H24N2O5
Canonical SMILES
CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)NCC(=O)OC3=CC=CC=C3OC
InChI
InChI=1S/C24H24N2O5/c1-16-8-10-17(11-9-16)24(29)19-13-12-18(26(19)2)14-22(27)25-15-23(28)31-21-7-5-4-6-20(21)30-3/h4-13H,14-15H2,1-3H3,(H,25,27)
InChIKey
CWJNMKKMGIAGDK-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
MED5 DM015187
135911
Unclear - Unclear 1 [2]
MED5 methyl ester DM016296
70449827
Unclear - Unclear 1 [3]
TOLMETIN DM014882
5509
Unclear - Unclear 1 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR010256 Amtolmetin guacil TOLMETIN Unclear - Unclear Unclear [4]
MR010257 Amtolmetin guacil MED5 Unclear - Unclear Unclear [2]
MR011054 Amtolmetin guacil MED5 methyl ester Unclear - Unclear Unclear [3]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Gastrosparing effect of new antiinflammatory drug amtolmetin guacyl in the rat: involvement of nitric oxide
3 Species difference in the in vitro and in vivo metabolism of amtolmetin guacil
4 Potential antioxidant activity of celecoxib and amtolmetin guacyl: in vitro studies

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