Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5441)
Drug Name
Sodium nitroprusside
Synonyms
Nitroprusside (Sodium); Sodium nitroprusside anhydrous; 14402-89-2; C5FeN6O.2Na; Nitropruss; Nitroprusid-natrium; Sodium nitroprussate; Nitroprussidnatrium [German]; C5FeN6O.2H2O.2Na; Sodium nitroprusside [USAN]; Na2[Fe(CN)5(NO)]; Sodium nitroprussiate dihydrate; Sodium nitrosylpentacyanoferrate; SCHEMBL3020702; CCRIS 1912; Sodium Nitroprusside (anhydrous); Disodium nitrosylpentacyanoferrate; Disodium pentacyanonitrosylferrate; CHEBI:29321; Nitroprussiate de sodium [French]; MolPort-003-926-312; disodium pentacyanidonitrosylfer
Indication Hypertension [ICD11: BA00-BA04] Approved [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 297.95 Topological Polar Surface Area 139
Heavy Atom Count 17 Rotatable Bond Count 0
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 14
Cross-matching ID
PubChem CID
11953895
ChEBI ID
CHEBI:9179
CAS Number
13755-38-9
TTD Drug ID
D07XVR
Formula
C5H4FeN6Na2O3
Canonical SMILES
[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[N-]=O.O.O.[Na+].[Na+].[Fe+4]
InChI
InChI=1S/5CN.Fe.NO.2Na.2H2O/c5*1-2;;1-2;;;;/h;;;;;;;;;2*1H2/q5*-1;+4;-1;2*+1;;
InChIKey
XRKMNJXYOFSTBE-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
CN- ions DM019915 N. A. Other reaction - Intraerythrocytic reaction 1 [2]
Cyanmethemoglobin DM002215 N. A. Other reaction - Intraerythrocytic reaction 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR012717 Sodium nitroprusside Cyanmethemoglobin Other reaction - Intraerythrocytic reaction Unclear [2]
MR012718 Sodium nitroprusside CN- ions Other reaction - Intraerythrocytic reaction Unclear [2]
References
1 Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.Crit Care Res Pract.2012;2012:290805.
2 LABEL:SODIUM NITROPRUSSIDE injection

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