Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5459)
Drug Name
Propoxyphene Hydrochloride
Synonyms Darvon; Dolene; Kesso-gesic; Prophene 65; Propoxyphene Hydrochloride 65; Darvon-n; Propoxyphene Napsylate
Indication Pain [ICD11: MG30-MG3Z] Approved [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 375.9 Topological Polar Surface Area 29.5
Heavy Atom Count 26 Rotatable Bond Count 9
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
15424
ChEBI ID
CHEBI:8498
CAS Number
1639-60-7
TTD Drug ID
D03HCZ
Formula
C22H30ClNO2
Canonical SMILES
CCC(=O)O[C@](CC1=CC=CC=C1)(C2=CC=CC=C2)[C@H](C)CN(C)C.Cl
InChI
InChI=1S/C22H29NO2.ClH/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;/h6-15,18H,5,16-17H2,1-4H3;1H/t18-,22+;/m1./s1
InChIKey
QMQBBUPJKANITL-MYXGOWFTSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Propoxyphene Hydrochloride Metabolite M16 DM015804
12372426
Unclear - Unclear 1 [3]
Propoxyphene Hydrochloride Metabolite M2 DM018665 N. A. Unclear - Unclear 1 [3]
Propoxyphene Hydrochloride Metabolite M5 DM018668 N. A. Unclear - Unclear 1 [3]
Propoxyphene Hydrochloride Metabolite M13 DM018667 N. A. Unclear - Unclear 2 [3]
Propoxyphene Hydrochloride Metabolite M17 DM015984
21257150
Unclear - Unclear 2 [3]
Propoxyphene Hydrochloride Metabolite M3 DM018666 N. A. Unclear - Unclear 2 [3]
Propoxyphene Hydrochloride Metabolite M5 DM018668 N. A. Unclear - Unclear 2 [3]
Propoxyphene Hydrochloride Metabolite M6 DM018671 N. A. Unclear - Unclear 2 [3]
Propoxyphene Hydrochloride Metabolite M14 DM018670 N. A. Unclear - Unclear 3 [3]
Propoxyphene Hydrochloride Metabolite M18 DM014876
4945
Unclear - Unclear 3 [3]
Propoxyphene Hydrochloride Metabolite M4 DM015805
12372430
Unclear - Unclear 3 [3]
Propoxyphene Hydrochloride Metabolite M6 DM018671 N. A. Unclear - Unclear 3 [3]
Propoxyphene Hydrochloride Metabolite M8 DM018669 N. A. Unclear - Unclear 4 [3]
⏷ Show the Full List of 13  DM(s)
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR010872 Propoxyphene Hydrochloride Propoxyphene Hydrochloride Metabolite M2 Unclear - Unclear Unclear [3]
MR010880 Propoxyphene Hydrochloride Propoxyphene Hydrochloride Metabolite M16 Unclear - Unclear Unclear [3]
MR010883 Propoxyphene Hydrochloride Propoxyphene Hydrochloride Metabolite M5 Unclear - Unclear Unclear [3]
MR010881 Propoxyphene Hydrochloride Metabolite M16 Propoxyphene Hydrochloride Metabolite M17 Unclear - Unclear Unclear [3]
MR010873 Propoxyphene Hydrochloride Metabolite M2 Propoxyphene Hydrochloride Metabolite M3 Unclear - Unclear Unclear [3]
MR010874 Propoxyphene Hydrochloride Metabolite M2 Propoxyphene Hydrochloride Metabolite M13 Unclear - Unclear Unclear [3]
MR010875 Propoxyphene Hydrochloride Metabolite M2 Propoxyphene Hydrochloride Metabolite M5 Unclear - Unclear Unclear [3]
MR010878 Propoxyphene Hydrochloride Metabolite M13 Propoxyphene Hydrochloride Metabolite M14 Unclear - Unclear Unclear [3]
MR010882 Propoxyphene Hydrochloride Metabolite M17 Propoxyphene Hydrochloride Metabolite M18 Unclear - Unclear Unclear [3]
MR010876 Propoxyphene Hydrochloride Metabolite M3 Propoxyphene Hydrochloride Metabolite M4 Unclear - Unclear Unclear [3]
MR010879 Propoxyphene Hydrochloride Metabolite M5 Propoxyphene Hydrochloride Metabolite M6 Unclear - Unclear Unclear [3]
MR010877 Propoxyphene Hydrochloride Metabolite M4 Propoxyphene Hydrochloride Metabolite M8 Unclear - Unclear Unclear [3]
⏷ Show the Full List of 12 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 DrugBank(Pharmacology-Metabolism):Propoxyphene Hydrochloride
3 Propoxyphene: pathways of metabolism in man and laboratory animals

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