Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5465)
Drug Name
Meclofenamate sodium
Synonyms .
Indication Rheumatoid arthritis [ICD11: FA20] Approved [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 318.1 Topological Polar Surface Area 52.2
Heavy Atom Count 20 Rotatable Bond Count 3
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
4038
ChEBI ID
CHEBI:6711
CAS Number
6385-02-0
TTD Drug ID
D0MN9K
Formula
C14H10Cl2NNaO2
Canonical SMILES
CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)[O-])Cl.[Na+]
InChI
InChI=1S/C14H11Cl2NO2.Na/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;/h2-7,17H,1H3,(H,18,19);/q;+1/p-1
InChIKey
OGPIIGMUPMPMNT-UHFFFAOYSA-M
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Meclofenamate sodium metabolite M1 DM016375
85951892
Oxidation - 4-hydroxylation 1 [2]
Meclofenamate sodium metabolite M2 DM020015
610738
Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR013708 Meclofenamate sodium Meclofenamate sodium metabolite M1 Oxidation - 4-hydroxylation CYP105A1 [2]
MR013709 Meclofenamate sodium Meclofenamate sodium metabolite M2 Unclear Unclear [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Vitamin D3 dihydroxylase (cyp105A1) DMEN027 Streptomyces griseolus
CPXE_STRGO
Not Available [2]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs) by Streptomyces griseolus CYP105A1 and its variants Drug Metab Pharmacokinet. 2022 Aug;45:100455. doi: 10.1016/j.dmpk.2022.100455.

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