Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5482)
Drug Name
Hydroxyamphetamine Hydrobromide
Synonyms Paredrine; 4-hydroxyamphetamine
Indication Horner syndrome [ICD11: 8D8A] Approved [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 232.12 Topological Polar Surface Area 46.2
Heavy Atom Count 12 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
9377
CAS Number
306-21-8
TTD Drug ID
D0W1RY
Formula
C9H14BrNO
Canonical SMILES
CC(CC1=CC=C(C=C1)O)N.Br
InChI
InChI=1S/C9H13NO.BrH/c1-7(10)6-8-2-4-9(11)5-3-8;/h2-5,7,11H,6,10H2,1H3;1H
InChIKey
RZCJLMTXBMNRAD-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
5-hydroxyindoleacetic acid DM005465
1826
Unclear - Unclear 1 [3]
Hydroxynorephedrine DM004779 N. A. Oxidation - Beta-hydroxylation 1 [4] , [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR007990 Hydroxyamphetamine Hydrobromide Hydroxynorephedrine Oxidation - Beta-hydroxylation DBO [4], [2]
MR007991 Hydroxyamphetamine Hydrobromide 5-hydroxyindoleacetic acid Unclear - Unclear MAOA [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Dopamine-beta-oxidase (DBO) DMEN741 Homo sapiens Not Available Not Available [2]
Monoamine oxidase type A (MAO-A) DME0044 Homo sapiens
AOFA_HUMAN
1.4.3.4
[3]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Dopamine-beta-oxidase activity in man, using hydroxyamphetamine as substrate
3 Inhibition of brain type A monoamine oxidase and 5-hydroxytryptamine uptake by two amphetamine metabolites, p-hydroxyamphetamine and p-hydroxynorephedrine
4 Urinary metabolites of p-hydroxyamphetamine in man, rat and guinea-pig

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