Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5484)
Drug Name
Macimorelin
Synonyms Solorel; AEZS-130; ARD-07; ARD-0705; EP-01572; EP-1572; JMV-1843
Indication Growth hormone deficiency [ICD11: 5A60-5A61] Approved [1]
Somatotropin deficiency [ICD11: ICD11: 5A60-5A61] Approved [2]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 474.6 Topological Polar Surface Area 145
Heavy Atom Count 35 Rotatable Bond Count 9
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
9804938
CAS Number
381231-18-1
TTD Drug ID
D0BV3J
Formula
C26H30N6O3
Canonical SMILES
CC(C)(C(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H](CC3=CNC4=CC=CC=C43)NC=O)N
InChI
InChI=1S/C26H30N6O3/c1-26(2,27)25(35)31-22(11-16-13-28-20-9-5-3-7-18(16)20)24(34)32-23(30-15-33)12-17-14-29-21-10-6-4-8-19(17)21/h3-10,13-15,22-23,28-29H,11-12,27H2,1-2H3,(H,30,33)(H,31,35)(H,32,34)/t22-,23-/m1/s1
InChIKey
UJVDJAPJQWZRFR-DHIUTWEWSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Macimorelin metabolite M1c DM016906 N. A. Oxidation - Hydroxylation 1 [4]
Macimorelin metabolite M2 DM016240
66791362
Oxidation - N-Dealkylation 1 [4]
Macimorelin metabolite M3 DM016907 N. A. Oxidation - N-Dealkylation 1 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR007726 Macimorelin Macimorelin metabolite M1c Oxidation - Hydroxylation Unclear [4]
MR007727 Macimorelin Macimorelin metabolite M2 Oxidation - N-Dealkylation Unclear [4]
MR007728 Macimorelin Macimorelin metabolite M3 Oxidation - N-Dealkylation Unclear [4]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[3]
References
1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
3 DrugBank(Pharmacology-Metabolism):Macimorelin
4 Comprehensive insights into the formation of metabolites of the ghrelin mimetics capromorelin, macimorelin and tabimorelin as potential markers for doping control purposes

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