Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME) | INTEDE

General Information of Drug (ID: DR5770)
Drug Name	Proflavine
Synonyms	PRL; Proflavin; Proflavina; Proflavinum; Profura; Progarmed; Isoflav base; Proflavine [INN]; Proflavine hemisulfate; Proflavina [INN-Spanish]; Proflavine Hemi-Sulfate; Proflavinum [INN-Latin]; AE-562/12222295; Acridine-3,6-diamine; 2,8-Diaminoacridine; 2,8-Diaminoacridine (European); 2,8-Diaminoacridinium; 3,6-ACRIDINEDIAMINE; 3,6-Acridinediamine hydrochloride; 3,6-Diamino-acridinium; 3,6-Diaminoacridine; 3,6-Diaminoacridine sulfate; 3,6-Diaminoacridinium; 3,7-Diamino-5-azaanthracene
Indication	Sepsis [ICD11: 1G40-1G41]				Approved	[1]
Structure
Structure	3D MOL			2D MOL
Pharmaceutical Properties	Molecular Weight		209.25	Topological Polar Surface Area		64.9
	Heavy Atom Count		16	Rotatable Bond Count		0
	Hydrogen Bond Donor Count		2	Hydrogen Bond Acceptor Count		3
Cross-matching ID	PubChem CID 7099 ChEBI ID CHEBI:8452 CAS Number 92-62-6 TTD Drug ID D08GSF Formula C13H11N3 Canonical SMILES C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N InChI InChI=1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2 InChIKey WDVSHHCDHLJJJR-UHFFFAOYSA-N

The Predicted Metabolic Roadmap of This Drug

The Full List of Predicted Drug Metabolites (PDM) of This Drug

PDM Name	PDM ID	PubChem ID	Reaction	PDM Level	Biosystem
Proflavine M1	PDM013795	12624266	Conjugation - N-Acetylation of arylamine	1	Human
Proflavine M2	PDM013796	N. A.	Conjugation - Glucuronidation of primary aromatic amine	1	Human

References
1	Drug information of Proflavine, 2008. eduDrugs.

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