Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5928)
Drug Name	Omidenepag isopropyl
Synonyms	Omidenepag isopropyl\|1187451-19-9\|DE-117\|eybelis\|Omidenepag isopropyl [USAN]\|G0G0H52U6K\|Omidenepag isopropyl (JAN)\|Propan-2-yl N-(6-((N-((4-(1H-pyrazol-1-yl)phenyl)methyl)pyridine-3-sulfonamido)methyl)pyridin-2-yl)glycinate\|OMIDENEPAG ISOPROPYL [JAN]\|Glycine, N-(6-((((4-(1H-pyrazol-1-yl)phenyl)methyl)(3-pyridinylsulfonyl)amino)methyl)-2-pyridinyl)-, 1-methylethyl ester\|Glycine, N-[6-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]-2-pyridinyl]-, 1-methylethyl ester\|Propan-2-yl N-{6-[(N-{[4-(1H-pyrazol-1-yl)phenyl]methyl}pyridine-3-sulfonamido)methyl]pyridin-2-yl}glycinate\|Eybelis (TN)\|UNII-G0G0H52U6K\|CHEMBL4297666\|SCHEMBL15414827\|TQR1222\|DTXSID001106409\|BCP26206\|EX-A4371\|BDBM50506549\|OMIDENEPAG ISOPROPYL [WHO-DD]\|AKOS040742334\|AT36244\|DB15071\|SB18739\|MS-29656\|HY-111406\|CS-0040499\|OMDI;DE-117; DE 117; DE117\|D10966\|Q27896252\|isopropyl 2-((6-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)pyridin-2-yl)amino)acetate\|N-[6-[[[[4-(1H-Pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]-2-pyridinyl]glycine 1-methylethyl ester\|propan-2-yl 2-[[6-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]pyridin-2-yl]amino]acetate
Pharmaceutical Properties	Molecular Weight	520.6	Topological Polar Surface Area	128
	Heavy Atom Count	37	Rotatable Bond Count	12
	Hydrogen Bond Donor Count	1	Hydrogen Bond Acceptor Count	9
Cross-matching ID	PubChem CID 44230999 Formula C26H28N6O4S Canonical SMILES CC(C)OC(=O)CNC1=CC=CC(=N1)CN(CC2=CC=C(C=C2)N3C=CC=N3)S(=O)(=O)C4=CN=CC=C4 InChI InChI=1S/C26H28N6O4S/c1-20(2)36-26(33)17-28-25-8-3-6-22(30-25)19-31(37(34,35)24-7-4-13-27-16-24)18-21-9-11-23(12-10-21)32-15-5-14-29-32/h3-16,20H,17-19H2,1-2H3,(H,28,30) InChIKey VIQCWEGEHRBLAC-UHFFFAOYSA-N

The Metabolic Roadmap of This Drug

The Full List of Drug Metabolites (DM) of This Drug

DM Name	DM ID	PubChem ID	Reaction	DM Level	REF
Omidenepag	DM005139	44230575	Hydrolysis - Ester hydrolysis	1	[2]

The Full List of Metabolic Reaction (MR) of This Drug

MR ID	Reactant	Product	MR Type	DME	REF
MR013197	Omidenepag isopropyl	Omidenepag	Hydrolysis - Ester hydrolysis	Unclear	[2]

Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug

DME Name	DME Info	Species	Uniprot ID	EC Number	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Homo sapiens	CP3A4_HUMAN	1.14.14.55	[1]

References
1	PubChem:Omidenepag isopropyl
2	Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl

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