Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000746)
Formula
SVG example
Reactant Dasatinib Product Dasatinib metabolite M6
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000747 Dasatinib Dasatinib metabolite M20 Oxidation - Hydroxylation Dasatinib [1]
MR000748 Dasatinib Dasatinib metabolite M24 Oxidation - Hydroxylation Dasatinib [1]
MR000744 Dasatinib Dasatinib metabolite M4 Oxidation - N-Dealkylation Dasatinib [1]
MR000745 Dasatinib Dasatinib metabolite M5 Oxidation - N-Oxidation Dasatinib [1], [2]
References
1 Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39.
2 Production of drug metabolites by human FMO3 in Escherichia coli Microb Cell Fact. 2020 Mar 20;19(1):74. doi: 10.1186/s12934-020-01332-1.

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