Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000804)
Formula Reactant Dexmedetomidine hydrochloride Product Dexmedetomidine N-glucuronidation
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
UDP-glucuronosyltransferase 2B10 (UGT2B10) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000803 Dexmedetomidine hydrochloride MPV-1305 Oxidation - Hydroxylation Dexmedetomidine hydrochloride [1]
MR000802 Dexmedetomidine hydrochloride MPV-1709 Conjugation - N-Methylation Dexmedetomidine hydrochloride [1]
References
1 Analytical method development for the simultaneous quantitation of dexmedetomidine and three potential metabolites in plasma J Chromatogr A. 1997 Feb 21;762(1-2):281-91. doi: 10.1016/s0021-9673(96)00965-x.

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