Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000821)
Formula
PTGS1 ...
SVG example
3-Hydroxylation
Reactant Diazepam Product Temazepam
Reactant Info Product Info
Metabolic Enzyme Prostaglandin G/H synthase 1 (COX-1) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - 3-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000819 Diazepam Desmethyldiazepam Unclear Diazepam [1], [2]
MR000820 Diazepam Oxazepam Oxidation - N-Demethylation Diazepam [1], [2], [3]
MR005847 Diazepam Medazepam metabolite Oxidation - N-demethylation Medazepam [4], [5]
MR001328 Diazepam Nordazepam Unclear Ketazolam [6], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005846 Medazepam metabolite Oxazepam Unclear Medazepam [4], [5]
References
1 DrugBank(Pharmacology-Metabolism)Diazepam
2 Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants. Drugs R D. 2022 Mar;22(1):43-50. doi: 10.1007/s40268-021-00375-y.
3 Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control. J Vet Pharmacol Ther. 2021 Sep;44(5):733-744. doi: 10.1111/jvp.12991.
4 Metabolism of 14C-medazepam hydrochloride in dog, rat and man
5 Plasma concentrations of medazepam and its metabolites after oral administration
6 Urinary diazepam metabolite distribution in a chronic pain population J Anal Toxicol. 2014 Apr;38(3):135-42. doi: 10.1093/jat/bku001.

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