Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000881)
Formula Reactant Diethyldlthiocarbamic acid Product Diethyldithiocarbamic acid methyl ester
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000884 Disulfiram Diethyldlthiocarbamic acid Unclear Disulfiram [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000883 Diethyldithiocarbamic acid methyl ester . Oxidation - Sulfoxidation Disulfiram [2]
MR000882 Diethyldithiocarbamic acid methyl ester Diethylthiocarbamic acid methyl ester Oxidation - Oxidative Desulphurylation Disulfiram [1]
References
1 Pharmacological effects of diethylthiocarbamic acid methyl ester, the active metabolite of disulfiram? Eur J Pharmacol. 1989 Aug 3;166(3):419-25. doi: 10.1016/0014-2999(89)90354-3.
2 Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation. Alcohol Clin Exp Res. 1998 Sep;22(6):1212-9.

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