Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR000940)
Formula	Hydrolysis
	Reactant	Erythromycin stearate		Product	Erythromycin
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Hydrolysis - Hydrolysis

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000939	Erythromycin	N-Desmethylerythromycin	Oxidation - Demethylation	Erythromycin stearate	[1], [2], [3]

References
1	PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics Pharmacogenet Genomics. 2017 Apr;27(4):164-167. doi: 10.1097/FPC.0000000000000270.
2	Effect of ABCC2 (MRP2) transport function on erythromycin metabolism Clin Pharmacol Ther. 2011 May;89(5):693-701. doi: 10.1038/clpt.2011.25.
3	Expression and characterization of human cytochrome P450 4F11: putative role in the metabolism of therapeutic drugs and eicosanoids. Toxicol Appl Pharmacol. 2004 Sep 15;199(3):295-304.

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