Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000991)
Formula
SVG example
Reactant Acitretin Product 13-cis-Acitretin
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011044 Acitretin 15-O-glucuronide Unclear - Unclear Acitretin [1]
MR010225 Acitretin Ro 12-7310 Unclear - Unclear Acitretin [1]
MR010223 Acitretin Ro 23-4293 Unclear - Unclear Acitretin [1]
MR011045 Acitretin Ro 23-4293 Metabolite M1 Unclear - Unclear Acitretin [1]
MR011055 Acitretin Tol-CoA Unclear - Unclear Acitretin [2]
MR011061 Acitretin TOL-GlcU Unclear - Unclear Acitretin [2]
MR011058 Acitretin Tol-OH Unclear - Unclear Acitretin [2]
MR000992 Acitretin Acitretin-CoA Other reaction - Ethyl Esterification Etretinate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010222 13-cis-Acitretin Ro 23-4750 Unclear - Unclear Acitretin [1]
MR013998 13-cis-Acitretin(Ro 13-7652) Ro-23-4750 Unclear - Unclear Acitretin [1]
MR000993 13-cis-Acitretin 13-cis-Etretinate Other reaction - Ethyl Esterification Etretinate [4]
References
1 Acitretin. A review of its pharmacology and therapeutic use
2 Identification of coenzyme A-related tolmetin metabolites in rats: relationship with reactive drug metabolites
3 In vitro metabolism of acitretin by human liver microsomes: evidence of an acitretinoyl-coenzyme A thioester conjugate in the transesterification to etretinate Biochem Pharmacol. 2000 Aug 15;60(4):507-16. doi: 10.1016/s0006-2952(00)00339-7.
4 A potentially new metabolic pathway: ethyl esterification of acitretin Xenobiotica. 1992 Aug;22(8):993-1002. doi: 10.3109/00498259209049905.

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