Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001120)
Formula
ndk
SVG example
Phosphorylation
Reactant Gemcitabine diphosphate Product Gemcitabine triphosphate
Reactant Info Product Info
Metabolic Enzyme Nucleoside diphosphate kinase (ndk) DME Info
Metabolic Type Other reaction - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001118 Gemcitabine Monophosphate Gemcitabine diphosphate Other reaction - Phosphorylation Gemcitabine [1]
MR012330 DFdCMP DFdCDP Unclear - Unclear CO-101 [2]
References
1 Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides Br J Clin Pharmacol. 2018 Jun;84(6):1279-1289. doi: 10.1111/bcp.13557.
2 Phase I study of oral CP-4126, a gemcitabine derivative, in patients with advanced solid tumors

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