Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001125)
Formula
UGT1A1 ...
SVG example
O-Glucuronidation
Reactant Gemfibrozil Product Gemfibrozil 1-beta-glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
Metabolic Type Conjugation - O-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001124 Gemfibrozil Gemfibrozil metabolite M1 Oxidation - 5-Hydroxylation Gemfibrozil [1], [2], [3]
MR001126 Gemfibrozil Gemfibrozil metabolite M2 Oxidation - 4-Hydroxylation Gemfibrozil [4], [5], [6]
MR001127 Gemfibrozil Gemfibrozil metabolite M4 Unclear Gemfibrozil [7], [5]
References
1 The metabolism of gemfibrozil Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):11-4.
2 Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides Br J Clin Pharmacol. 2018 Jun;84(6):1279-1289. doi: 10.1111/bcp.13557.
3 Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet. 1998 Feb;34(2):155-62.
4 Congenital Zika syndrome in non-endemic regions J Perinat Med. 2018 Sep 25;46(7):819. doi: 10.1515/jpm-2017-0403.
5 Biodegradation of emerging organic pollutant gemfibrozil: Mechanism, kinetics and pathway modelling. Bioresour Technol. 2023 Apr;374:128749. doi: 10.1016/j.biortech.2023.128749.
6 Metabolic Activation of Gemfibrozil Mediated by Cytochrome P450 Enzymes and Sulfotransferases. Chem Res Toxicol. 2022 Jul 18;35(7):1257-1266. doi: 10.1021/acs.chemrestox.2c00054.
7 Gemfibrozil metabolite inhibits in vitro low-density lipoprotein (LDL) oxidation and diminishes cytotoxicity induced by oxidized LDL Metabolism. 2000 Apr;49(4):479-85. doi: 10.1016/s0026-0495(00)80012-8.

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