Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001143)
Formula
SVG example
Hydroxylation
Reactant Glipizide Product 3-trans-hydroxyglipizide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001141 Glipizide 3-cis-hydroxyglipizide Oxidation - Hydroxylation Glipizide [1], [2]
MR001142 Glipizide 4-trans-hydroxyglipizide Oxidation - Hydroxylation Glipizide [1], [2]
MR001144 Glipizide 4-trans-OH-glipizide Oxidation - Hydroxylation Glipizide [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Simultaneous determination of glipizide and its four hydroxylated metabolites in human urine using LC-MS/MS and its application in urinary phenotype study J Pharm Biomed Anal. 2017 May 30;139:179-186. doi: 10.1016/j.jpba.2017.03.005.
3 U. S. FDA Label -Glipizide

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