Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR001171)
Formula	Glucuronidation
	Reactant	Imrecoxib metabolite M2		Product	Imrecoxib metabolite M6
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Conjugation - Glucuronidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001173	Imrecoxib metabolite M1	Imrecoxib metabolite M2	Unclear	Imrecoxib	[1], [2]
MR001168	Imrecoxib metabolite M4	Imrecoxib metabolite M2	Oxidation - Oxidation	Imrecoxib	[3]

References
1	Differences in the In Vivo and In Vitro Metabolism of Imrecoxib in Humans: Formation of the Rate-Limiting Aldehyde Intermediate Drug Metab Dispos. 2018 Sep;46(9):1320-1328. doi: 10.1124/dmd.118.081182.
2	Comparative Pharmacokinetics and Safety of Imrecoxib, a Novel Selective Cyclooxygenase-2 Inhibitor, in Elderly Healthy Subjects. Drug Des Devel Ther. 2022 Nov 8;16:3865-3876. doi: 10.2147/DDDT.S387508.
3	Metabolism and excretion of imrecoxib in rat Xenobiotica. 2006 May;36(5):441-55. doi: 10.1080/00498250600595524.

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