Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001212)
Formula
SVG example
Hydroxylation
Reactant Irbesartan derivative M5 Product Irbesartan derivative M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001216 Irbesartan Irbesartan derivative M5 Oxidation - Hydroxylation Irbesartan [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001209 Irbesartan derivative M4 Irbesartan derivative M1 Oxidation - Hydroxylation Irbesartan [2]
MR001213 Irbesartan derivative M7 Irbesartan derivative M1 Oxidation - Hydroxylation Irbesartan [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001211 Irbesartan derivative M1 Irbesartan derivative M2 Oxidation - Oxidation Irbesartan [2]
References
1 Biotransformation of irbesartan in man Drug Metab Dispos. 1998 May;26(5):408-17.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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