Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001239)
Formula
SVG example
Acetylation
Reactant Isoniazid Product Acetylisoniazid
Reactant Info Product Info
Metabolic Type Conjugation - Acetylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001240 Isoniazid Hydrazine Unclear Isoniazid [1], [2]
MR001241 Isoniazid Isonicotinic acid Unclear Isoniazid [1]
MR014190 Isoniazid Isonicotinic acyl-NADH Multi-steps Reaction - Reduction; Oxidation Isoniazid [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001232 Acetylisoniazid Acethydrazide Unclear Isoniazid [1]
MR001233 Acetylisoniazid Isonicotinic acid Unclear Isoniazid [1]
References
1 Exploration of inhibition potential of isoniazid and its metabolites towards CYP2E1 in human liver microsomes through LC-MS/MS analysis J Pharm Biomed Anal. 2021 Sep 5;203:114223. doi: 10.1016/j.jpba.2021.114223.
2 Quantitative Analysis of Isoniazid and Its Four Primary Metabolites in Plasma of Tuberculosis Patients Using LC-MS/MS. Molecules. 2022 Dec 6;27(23):8607. doi: 10.3390/molecules27238607.
3 The tuberculosis prodrug isoniazid bound to activating peroxidases

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