Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001244)
Formula
SVG example
Denitration
Reactant Isosorbide 2-nitrate Product Isosorbide
Reactant Info Product Info
Metabolic Type Other reaction - Denitration
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001246 Isosorbide dinitrate Isosorbide 2-nitrate Other reaction - Denitration Isosorbide dinitrate [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001249 Isosorbide mononitrate Isosorbide Other reaction - Denitrosylation Isosorbide mononitrate [3]
MR001243 Isosorbide 5-mononitrate Isosorbide Other reaction - Denitration Isosorbide dinitrate [1], [2]
References
1 Isosorbide dinitrate bioavailability, kinetics, and metabolism Clin Pharmacol Ther. 1985 Aug;38(2):140-9. doi: 10.1038/clpt.1985.150.
2 Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration Eur J Clin Pharmacol. 1985;27(6):637-44. doi: 10.1007/BF00547041.
3 Pharmacokinetics of isosorbide mononitrate Am J Cardiol. 1992 Nov 27;70(17):61G-66G. doi: 10.1016/0002-9149(92)90028-w.

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