Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001286)
Formula
SVG example
Reactant Ivermectin metabolite M3 Product 3''\O\demethyl, 4\hydroxymethyl ivermectin
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001290 Ivermectin Ivermectin metabolite M3 Oxidation - Hydroxylation Ivermectin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001288 Ivermectin 3''\O\demethyl, 4\hydroxymethyl ivermectin Unclear Ivermectin [1]
MR001284 3''-O-Desmethyl-ivermectin B1a 3''\O\demethyl, 4\hydroxymethyl ivermectin Unclear Ivermectin [1], [2], [3]
MR001285 3''-O-Desmethyl-ivermectin B1b 3''\O\demethyl, 4\hydroxymethyl ivermectin Unclear Ivermectin [1], [2], [3]
References
1 Identification of the metabolites of ivermectin in humans Pharmacol Res Perspect. 2021 Feb;9(1):e00712. doi: 10.1002/prp2.712.
2 Ivermectin metabolites reduce Anopheles survival. Sci Rep. 2023 May 19;13(1):8131. doi: 10.1038/s41598-023-34719-2.
3 Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes. Malar J. 2023 Jun 24;22(1):194. doi: 10.1186/s12936-023-04624-0.

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