Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR001317)
Formula	Glucuronidation
	Reactant	4-hydroxynorketamine		Product	4-hydroxynorketamine glucuronide
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Conjugation - Glucuronidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001320	4-hydroxyketamine	4-hydroxynorketamine	Oxidation - N-Demethylation	Ketamine	[1], [2]
MR001313	Norketamine	4-hydroxynorketamine	Oxidation - Hydoxylation	Ketamine	[1], [3]

References
1	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2	Metabolism and metabolomics of ketamine: a toxicological approach. Forensic Sci Res. 2017 Feb 20;2(1):2-10.
3	The clinical toxicology of ketamine. Clin Toxicol (Phila). 2023 Jun;61(6):415-428. doi: 10.1080/15563650.2023.2212125.

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