Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001405)
Formula
PGK2 ...
SVG example
Phosphorylation
Reactant Lamivudine diphosphate Product Lamivudine triphosphate
Reactant Info Product Info
Metabolic Enzyme Phosphoglycerate kinase 2 (PGK2) DME Info
Nucleoside diphosphate kinase (NME4) DME Info
Metabolic Type Other reaction - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001404 Lamivudine monophosphate Lamivudine diphosphate Other reaction - Phosphorylation lamivudine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001406 Lamivudine triphosphate Lamivudine metabolite M Unclear lamivudine [1], [3]
References
1 Model for intracellular Lamivudine metabolism in peripheral blood mononuclear cells ex vivo and in human immunodeficiency virus type 1-infected adolescents. Antimicrob Agents Chemother. 2006 Aug;50(8):2686-94.
2 Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine Antimicrob Agents Chemother. 2007 Jun;51(6):2130-5. doi: 10.1128/AAC.01543-06.
3 An open-label, randomized, single intravenous dosing study to investigate the effect of fixed-dose combinations of tenofovir/lamivudine or atazanavir/ritonavir on the pharmacokinetics of remdesivir in Ugandan healthy volunteers (RemTLAR). Trials. 2021 Nov 23;22(1):831. doi: 10.1186/s13063-021-05752-1.

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