Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001419)
Formula Reactant Reactive Quinoneimine metabolite Product Glutathione adducts
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001418 O-dealkylated lapatinib Reactive Quinoneimine metabolite Unclear Lapatinib ditosylate [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001420 Reactive Quinoneimine metabolite Quinoneimine-GSH conjugate Conjugation - Conjugation Lapatinib ditosylate [2]
References
1 Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib Drug Metab Dispos. 2011 Jun;39(6):1022-30. doi: 10.1124/dmd.110.037531.
2 Detoxication versus Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib Drug Metab Dispos. 2021 Mar;49(3):233-244. doi: 10.1124/dmd.120.000236.

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