Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001424)
Formula
UGT
SVG example
Glucuronidation
Reactant Lapatinib ditosylate metabolite M1 Product Lapatinib ditosylate metabolite M1-glucuronide conjugate
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001427 Lapatinib ditosylate O-dealkylated lapatinib Oxidation - O-Dealkylation Lapatinib ditosylate [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001425 Lapatinib ditosylate metabolite M1 Lapatinib ditosylate metabolite M1-sulfate conjugate Conjugation - Sulfation Lapatinib ditosylate [2], [3], [2]
MR001426 Lapatinib ditosylate metabolite M1 Lapatinib ditosylate metabolite M3 Oxidation - Oxidation Lapatinib ditosylate [2], [3], [2]
MR001418 O-dealkylated lapatinib Reactive Quinoneimine metabolite Unclear Lapatinib ditosylate [1]
References
1 Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib Drug Metab Dispos. 2011 Jun;39(6):1022-30. doi: 10.1124/dmd.110.037531.
2 Detoxication versus Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib Drug Metab Dispos. 2021 Mar;49(3):233-244. doi: 10.1124/dmd.120.000236.
3 Case Study 11: Considerations for Enzyme Mapping Experiments-Interaction Between the Aldehyde Oxidase Inhibitor Hydralazine and Glutathione. Methods Mol Biol. 2021;2342:809-823. doi: 10.1007/978-1-0716-1554-6_30.

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