Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001441)
Formula
SVG example
Hydrolysis
Reactant Lenvatinib mesylate Product Lenvatinib mesylate metabolite M30
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001442 Lenvatinib mesylate . Unclear Lenvatinib mesylate [1]
MR001439 Lenvatinib mesylate Lenvatinib mesylate metabolite M1 Oxidation - Dealkylation Lenvatinib mesylate [2]
MR001437 Lenvatinib mesylate Lenvatinib mesylate metabolite M2 Oxidation - Dealkylation Lenvatinib mesylate [2]
MR001440 Lenvatinib mesylate Lenvatinib mesylate metabolite M3 Oxidation - N-Oxidation Lenvatinib mesylate [2]
MR001438 Lenvatinib mesylate Lenvatinib mesylate metabolite M32 Hydrolysis - Hydrolysis Lenvatinib mesylate [2]
References
1 Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer. Sci Rep. 2019 Apr 1;9(1):5404.
2 Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison Invest New Drugs. 2016 Jun;34(3):300-18. doi: 10.1007/s10637-016-0342-y.

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