Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001499)
Formula Reactant Levodopa Product Levodopa Methylated metabolite
Reactant Info Product Info
Metabolic Type Conjugation - Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001500 Levodopa 3-O-Methyldopa Conjugation - Methylation Levodopa [1], [2], [3], [4]
MR001498 Levodopa Dopamine Oxidation - Decarboxylation Levodopa [5]
MR009124 Levodopa Dopamine Unclear - Unclear ABBV-951 [6]
References
1 Motor complications, levodopa metabolism and progression of Parkinson's disease Expert Opin Drug Metab Toxicol. 2011 Jul;7(7):847-55. doi: 10.1517/17425255.2011.575779.
2 Impact of the catechol-O-methyltransferase Val158Met polymorphism on the pharmacokinetics of L-dopa and its metabolite 3-O-methyldopa in combination with entacapone. J Neural Transm (Vienna). 2021 Jan;128(1):27-36. doi: 10.1007/s00702-020-02267-y.
3 Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia. Sci Adv. 2021 Jan 6;7(2):eabe5948. doi: 10.1126/sciadv.abe5948. Print 2021 Jan.
4 Pharmacokinetics of Levodopa and 3-O-Methyldopa in Parkinsonian Patients Treated with Levodopa and Ropinirole and in Patients with Motor Complications. Pharmaceutics. 2021 Sep 3;13(9):1395. doi: 10.3390/pharmaceutics13091395.
5 Complexity of dopamine metabolism. Cell Commun Signal. 2013 May 17;11(1):34.
6 Scalable Asymmetric Syntheses of Foslevodopa and Foscarbidopa Drug Substances for the Treatment of Parkinson's Disease

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.