Details of the Metabolic Reaction (MR)
General Information of This Metabolic Reaction (MR) (ID: MR001651) | ||||||
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Formula |
UGT1A9
...
O-Glucuronidation
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Reactant | 17alpha-Ethinylestradiol | Product | N-desmethylzopiclone metabolite | |||
Reactant Info | Product Info | |||||
Metabolic Enzyme | UDP-glucuronosyltransferase 1A9 (UGT1A9) | DME Info | ||||
UDP-glucuronosyltransferase 1A4 (UGT1A4) | DME Info | |||||
UDP-glucuronosyltransferase 2B7 (UGT2B7) | DME Info | |||||
UDP-glucuronosyltransferase 1A1 (UGT1A1) | DME Info | |||||
UDP-glucuronosyltransferase 1A3 (UGT1A3) | DME Info | |||||
Metabolic Type | Conjugation - O-Glucuronidation | |||||
References | ||||||
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1 | Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. | |||||
2 | Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors. J Clin Pharmacol. 1997 Mar;37(3):193-200. | |||||
3 | Fast and Sensitive Screening of Oxandrolone and Its Major Metabolite 17-Epi-Oxandrolone in Human Urine by UHPLC-MS/MS with On-Line SPE Sample Pretreatment | |||||
4 | The bioaccumulation and biotransformation of synthetic estrogen quinestrol in crucian carp | |||||
5 | Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019. | |||||
6 | Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072. | |||||
7 | Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol Drug Metab Dispos. 2004 Nov;32(11):1299-303. doi: 10.1124/dmd.32.11.. |
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