Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001653)
Formula
SVG example
O-Demethylation
Reactant Mestranol Product 17beta-Ethinylestradiol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001652 Mestranol 17alpha-Ethinylestradiol Oxidation - O-Demethylation Mestranol [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors. J Clin Pharmacol. 1997 Mar;37(3):193-200.

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