Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR001773)
Formula	N-Oxidation
	Reactant	Nizatidine		Product	Nizatidine N2-oxide metabolite
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Oxidation - N-Oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001772	Nizatidine	N2-monodes-methylnizatidine	Oxidation - N-Demethylation	Nizatidine	[1], [2]
MR001774	Nizatidine	Nizatidine sulfoxide metabolite	Oxidation - Sulfoxidation	Nizatidine	[3]

References
1	Hemofiltrability of histamine H2-receptor antagonist, nizatidine, and its metabolites in patients with renal failure J Clin Pharmacol. 1993 Apr;33(4):324-9. doi: 10.1002/j.1552-4604.1993.tb04664.x.
2	Determination of nizatidine and two of its main metabolites in human serum using high-performance liquid chromatography J Chromatogr. 1990 Aug 3;529(2):369-76. doi: 10.1016/s0378-4347(00)83843-8.
3	Nizatidine, an H2-blocker. Its metabolism and disposition in man Drug Metab Dispos. 1986 Mar-Apr;14(2):175-82.

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