Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002093)
Formula Reactant 3alpha-isopravastatin Product 7-hydroxy-3alpha-isopravastatin
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002097 Pravastatin 3alpha-isopravastatin Other reaction - Isomerization Pravastatin [1], [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002092 3alpha-isopravastatin 5,6-epoxy-3alpha-isopravastatin Oxidation - Oxidation Pravastatin [1], [2], [3]
References
1 Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15;878(28):2751-9. doi: 10.1016/j.jchromb.2010.08.015.
2 Effects of mineral oil administration on the pharmacokinetics, metabolism and pharmacodynamics of atorvastatin and pravastatin in mice and dogs Eur J Pharm Sci. 2021 Jun 1;161:105776. doi: 10.1016/j.ejps.2021.105776.
3 Disposition and metabolism of pravastatin sodium in rats, dogs and monkeys Eur J Drug Metab Pharmacokinet. 1992 Apr-Jun;17(2):103-13. doi: 10.1007/BF03188778.

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