Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002108)
Formula
SVG example
Glucuronidation
Reactant Oxazepam Product Oxazepam glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002863 Oxazepam . Oxidation - Deamination Oxazepam [1]
MR004427 Oxazepam Oxazepam glucuronides Unclear Nordazepam [2]
MR002379 Oxazepam Temazepam metabolite M1 Conjugation - Conjugation Temazepam [3]
MR002109 Oxazepam 4'-hydroxyoxazepam Oxidation - Hydroxylation Prazepam [4], [5]
References
1 Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures. Xenobiotica. 2000 Jan;30(1):27-46.
2 Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver
3 Pharmacokinetics and metabolism of temazepam in man and several animal species Br J Clin Pharmacol. 1979;8(1):23S-29S. doi: 10.1111/j.1365-2125.1979.tb00451.x.
4 Prazepam metabolism by man Clin Pharmacol Ther. 1970 Nov-Dec;11(6):890-7. doi: 10.1002/cpt1970116890.
5 Prazepam metabolites in dog urine J Pharm Sci. 1970 Mar;59(3):322-5. doi: 10.1002/jps.2600590309.

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