Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002126)
Formula
SVG example
Hydroxylation
Reactant Prednisolone Product 6alpha-hydroxy-prednisolone (M-VII)
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002125 Prednisolone 17alpha,21-dihydroxy-pregnan-1,4,6-trien-3,11,30-trione (M-XVII) Unclear Prednisolone [1]
MR002123 Prednisolone 20alpha-dihydro-prednisolone (M-III) Unclear Prednisolone [1]
MR002128 Prednisolone 20alpha-dihydro-prednisone (M-V) Unclear Prednisolone [1]
MR002124 Prednisolone 20beta-dihydro-prednisolone (M-II) Unclear Prednisolone [1]
MR002127 Prednisolone 6beta-hydroxy-prednisolone(M-VI) Oxidation - Hydroxylation Prednisolone [1]
MR002122 Prednisolone Delta6-prednisolone (M-XI) Unclear Prednisolone [1]
MR002129 Prednisolone Prednisone Unclear Prednisolone [1]
MR002779 Prednisolone 6beta-hydroxy-prednisolone(M-VI) Unclear Prednisone [2]
MR002776 Prednisolone 20alpha-dihydro-prednisolone (M-III) Unclear Prednisone [1]
MR002777 Prednisolone 20beta-dihydro-prednisolone (M-II) Unclear Prednisone [1]
MR002775 Prednisolone Delta6-prednisolone (M-XI) Unclear Prednisone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002113 6alpha-hydroxy-prednisolone (M-VII) 6alpha,11beta,17alpha,20beta,21-pentahydroxypregnan-1,4-diene-3-one (M-X) Unclear Prednisolone [1]
MR002760 6alpha-hydroxy-prednisolone (M-VII) 6alpha,11beta,17alpha,20beta,21-pentahydroxypregnan-1,4-diene-3-one (M-X) Unclear Prednisone [1]
References
1 Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS J Mass Spectrom. 2015 Mar;50(3):633-42. doi: 10.1002/jms.3571.
2 Pharmacokinetic and pharmacoimmunodynamic interactions between prednisolone and sirolimus in adrenalectomized rats. J Pharmacokinet Biopharm. 1999 Feb;27(1):1-21.

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