Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002202)
Formula
AOX1 ...
SVG example
Oxidation
Reactant Pyrazinamide Product 5-hydroxypyrazinamide
Reactant Info Product Info
Metabolic Enzyme Aldehyde oxidase (AOX1) DME Info
Xanthine dehydrogenase/oxidase (XDH) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002201 Pyrazinamide Pyrazinoic acid Oxidation - Oxidation Pyrazinamide [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002200 5-hydroxypyrazinamide 5-hydroxypyrazinoic acid Unclear Pyrazinamide [1], [2], [3]
References
1 Factors Affecting the Pharmacokinetics of Pyrazinamide and Its Metabolites in Patients Coinfected with HIV and Implications for Individualized Dosing Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0004621. doi: 10.1128/AAC.00046-21.
2 Metabolism and Hepatotoxicity of Pyrazinamide, an Antituberculosis Drug Drug Metab Dispos. 2021 Aug;49(8):679-682. doi: 10.1124/dmd.121.000389.
3 Determination of pyrazinamide and its main metabolites in rat urine by high-performance liquid chromatography J Chromatogr B Biomed Sci Appl. 1997 Aug 1;695(2):365-72. doi: 10.1016/s0378-4347(97)00175-8.

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