Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002226)
Formula Reactant Glutathione conjugates Product Selenide
Reactant Info Product Info
Metabolic Enzyme Thioredoxin reductase TR1 (TXNRD1) DME Info
Glutathione reductase (GSR) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002236 Selenium Glutathione conjugates Conjugation - Conjugation Selenium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002227 Selenide Selenocystein Reduction - Reduction Selenium [1], [2], [3]
MR002228 Selenide Selenophosphate Reduction - Reduction Selenium [4], [5], [6]
References
1 Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66.
2 Biochemistry, Antioxidants. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 JanC.
3 Enhanced selenocysteine biosynthesis for seleno-methylselenocysteine production in Bacillus subtilis. Appl Microbiol Biotechnol. 2023 May;107(9):2843-2854. doi: 10.1007/s00253-023-12482-8.
4 SEPHS1: Its evolution, function and roles in development and diseases. Arch Biochem Biophys. 2022 Nov 15;730:109426. doi: 10.1016/j.abb.2022.109426.
5 The selenophosphate synthetase family: A review. Free Radic Biol Med. 2022 Nov 1;192:63-76. doi: 10.1016/j.freeradbiomed.2022.09.007.
6 Constitutive Oxidative Stress by SEPHS1 Deficiency Induces Endothelial Cell Dysfunction. Int J Mol Sci. 2021 Oct 28;22(21):11646. doi: 10.3390/ijms222111646.

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