Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002600)
Formula Reactant 3'-hydroxydiclofenac Product 3',4'-hydroxy diclofenac
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - 4'-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002612 Diclofenac sodium 3'-hydroxydiclofenac Oxidation - 3'-Hydroxylation Diclofenac sodium [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002601 3',4'-hydroxy diclofenac 3'-hydroxy-4'-methoxy diclofenac Conjugation - O-Methylation Diclofenac sodium [3]
References
1 Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis Eur J Clin Pharmacol. 1983;25(3):389-94. doi: 10.1007/BF01037953.
2 Simultaneous determination of diclofenac sodium and its hydroxy metabolites by capillary column gas chromatography with electron-capture detection J Chromatogr. 1981 Nov 6;217:263-71. doi: 10.1016/s0021-9673(00)88081-4.
3 DrugBank(Pharmacology-Metabolism)Diclofenac sodium

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