Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002645)
Formula
SVG example
Reactant Estrone Product 16alpha hydroxyestrone
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002705 Estrone 15alpha-OH-estrone Unclear Estrone [1]
MR002706 Estrone 16alpha-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002707 Estrone 16beta-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002696 Estrone 2-hydroxyestrone Oxidation - 2-Hydroxylation Estrone [2]
MR002699 Estrone 2-hydroxyestrone sulfate Unclear Estrone [3]
MR002697 Estrone 4-hydroxyestrone Oxidation - 4-Hydroxylation Estrone [2]
MR002700 Estrone 4-hydroxyestrone sulfate Unclear Estrone [3]
MR002701 Estrone 4-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002702 Estrone 6alpha-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002703 Estrone 6beta-estrone Unclear Estrone [1]
MR002704 Estrone 7alpha-OH-estrone Unclear Estrone [1]
MR002698 Estrone Estrone glucuronide Conjugation - Glucuronidation Estrone [3]
MR002708 Estrone Estrone sulfate Unclear Estrone [3]
MR004102 Estrone Estriol Oxidation - Hydrolyzationn Conjugated estrogens [4]
MR013321 Estrone Estrone sulfate Unclear E-3A [5]
MR002646 Estrone Estrone sulfate Unclear Estradiol acetate [5]
MR002669 Estrone Estrone sulfate Unclear Estradiol cypionate [5]
MR002692 Estrone Estrone sulfate Unclear Estradiol valerate [5]
MR003151 Estrone Estrone sulfate Unclear Dehydroepiandrosterone [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013311 16-alpha hydroxyestrone 17-Epiestriol Unclear E-3A [7]
MR013312 16-alpha hydroxyestrone Estriol Unclear E-3A [7]
MR002638 16alpha hydroxyestrone 17-Epiestriol Unclear Estradiol acetate [7]
MR002661 16alpha hydroxyestrone 17-Epiestriol Unclear Estradiol cypionate [7]
MR002684 16alpha hydroxyestrone 17-Epiestriol Unclear Estradiol valerate [7]
MR002639 16alpha hydroxyestrone Estriol Unclear Estradiol acetate [7]
MR002662 16alpha hydroxyestrone Estriol Unclear Estradiol cypionate [7]
MR002685 16alpha hydroxyestrone Estriol Unclear Estradiol valerate [7]
⏷ Show the Full List of MR
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
2 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
3 DrugBank(Pharmacology-Metabolism)Estrone
4 DrugBank(Pharmacology-Metabolism):Conjugated estrogens
5 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
6 Dehydroepiandrosterone Research: Past, Current, and Future Vitam Horm. 2018;108:1-28. doi: 10.1016/bs.vh.2018.02.002.
7 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.

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