Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002848)
Formula
SVG example
O-Methylation
Reactant Epinephrine hydrochloride Product Metanephrine
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Conjugation - O-Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002849 Epinephrine hydrochloride Dihydroxymandelic acid Unclear Epinephrine hydrochloride [1]
MR002847 Epinephrine hydrochloride Epinephrine glucuronide metabolite Conjugation - Glucuronidation Epinephrine hydrochloride [2]
MR002846 Epinephrine hydrochloride Epinephrine sulfate metabolite Conjugation - Sulfation Epinephrine hydrochloride [3]
References
1 Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats. J Pharmacol Exp Ther. 1994 Mar;268(3):1242-51.
2 LABEL:?ARTICAINE HYDROCHLORIDE AND EPINEPHRINE injection, solution
3 Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. Biochem Biophys Res Commun. 2005 Sep 23;335(2):417-23.

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