Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002961)
Formula
SVG example
Hydroxylation
Reactant Nicotine Product 2'-hydroxynicotine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002960 Nicotine (S)-Nicotine delta-1',5'-iminium ion Oxidation - Heteroring Dehydrogenation Nicotine [1]
MR002959 Nicotine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol Unclear Nicotine [2]
MR002958 Nicotine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Unclear Nicotine [2]
MR002963 Nicotine Cotinine Unclear Nicotine [2]
MR002954 Nicotine N-Methylnicotinium Unclear Nicotine [3]
MR002955 Nicotine Nicotine glucuronide metabolite Conjugation - Glucuronidation Nicotine [1]
MR002953 Nicotine Nicotine imine Unclear Nicotine [3]
MR002957 Nicotine Nicotine-1'-N-oxide Oxidation - 1'-N-Oxidation Nicotine [3]
MR002956 Nicotine Norcotinine Unclear Nicotine [2]
MR002952 Nicotine Nornicotine Unclear Nicotine [2]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 DrugBank(Pharmacology-Metabolism)Nicotine
3 U. S. FDA Label -Nicotine

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.