Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003009)
Formula
SVG example
Reactant Erlotinib M14 Product Erlotinib M17
Reactant Info Product Info
Metabolic Enzyme DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003018 Erlotinib hydrochloride Erlotinib M14 Oxidation - O-demethylation Erlotinib hydrochloride [1], [2]
MR003007 Erlotinib M2 Erlotinib M14 Oxidation - O-demethylation Erlotinib hydrochloride [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003008 Erlotinib M14 Erlotinib M10 Conjugation - O-glucuronidation Erlotinib hydrochloride [1]
MR003011 Erlotinib M14 Erlotinib M12 Conjugation - O-glucuronidation Erlotinib hydrochloride [1]
MR003010 Erlotinib M14 Erlotinib M18 Conjugation - O-glucuronidation Erlotinib hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003019 Erlotinib hydrochloride Erlotinib M17 Unclear Erlotinib hydrochloride [1]
MR003017 Erlotinib M16 Erlotinib M17 Conjugation - O-glucuronidation Erlotinib hydrochloride [1]
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
2 Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.

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