Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003084)
Formula Reactant Dobutamine hydrochloride Product 3-O-methyl dobutamine
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Conjugation - Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003085 Dobutamine hydrochloride Acid-hydrolyzed dobutamine Unclear Dobutamine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003083 3-O-methyl dobutamine 3-O-methyldobutamine sulfate Conjugation - Conjugation Dobutamine hydrochloride [2], [1]
References
1 3-O-methyldobutamine, a major metabolite of dobutamine in humans Drug Metab Dispos. 2002 May;30(5):519-24. doi: 10.1124/dmd.30.5.519.
2 Catechol-O-methyltransferase: substrate-specificity and stereoselectivity for beta-adrenoceptor agents. Xenobiotica. 1986 Jan;16(1):47-52.

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