Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003172)
Formula
CYP2C9 ...
SVG example
Oxidation
Reactant Phenytoin Product Phenytoin arene-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002036 Phenytoin Phenytoin dihydrodiol Oxidation - Dihydroxylation; Oxidation Phenytoin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002029 Phenytoin arene-oxide Hydroxyphenytoin Unclear Phenytoin [2]
MR003162 Phenytoin arene-oxide Hydroxyphenytoin Unclear Fosphenytoin sodium [2]
MR003163 Phenytoin arene-oxide Phenytoin dihydrodiol Oxidation - Dihydroxylation Fosphenytoin sodium [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
3 DrugBank(Pharmacology-Metabolism)Fosphenytoin sodium

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