Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003231)
Formula
SVG example
Hydrolysis
Reactant Daunorubicinol Product Deoxydaunorubicinol aglycone
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003242 Daunorubicin Daunorubicinol Reduction - Reduction Daunorubicin [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003232 Daunorubicinol Daunorubicinol aglycone Hydrolysis - Hydrolysis Daunorubicin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003240 Deoxydaunorubicin aglycone Deoxydaunorubicinol aglycone Reduction - Reduction Daunorubicin [1]
MR003233 Deoxydaunorubicinol aglycone Deoxydaunorubicinol aglycone Reduction - Reduction Daunorubicin [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003234 Deoxydaunorubicinol aglycone Demethyl deoxydaunorubicinol aglycone Oxidation - Demethylation Daunorubicin [1]
MR003235 Deoxydaunorubicinol aglycone Demethyl deoxydaunorubicinol aglycone-4-O-beta-glucuronide metabolite Conjugation - Glucuronidation Daunorubicin [1]
MR003236 Deoxydaunorubicinol aglycone Demethyl deoxydaunorubicinol aglycone-4-O-sulfate metabolite Conjugation - Sulfation Daunorubicin [1]
MR003233 Deoxydaunorubicinol aglycone Deoxydaunorubicinol aglycone Reduction - Reduction Daunorubicin [1]
MR003237 Deoxydaunorubicinol aglycone Deoxydaunorubicinol aglycone-13-O-beta-glucuronide Conjugation - Glucuronidation Daunorubicin [1]
References
1 Daunorubicin metabolites in human urine J Pharmacol Exp Ther. 1975 Oct;195(1):41-9.
2 Daunorubicin and Its Active Metabolite Pharmacokinetic Profiles in Acute Myeloid Leukaemia Patients: A Pharmacokinetic Ancillary Study of the BIG-1 Trial. Pharmaceutics. 2022 Apr 5;14(4):792. doi: 10.3390/pharmaceutics14040792.
3 The electromembrane extraction of pharmaceutical compounds from animal tissues. Anal Chim Acta. 2021 Sep 8;1177:338742. doi: 10.1016/j.aca.2021.338742.
4 Electromembrane extraction of anthracyclines from plasma: Comparison with conventional extraction techniques. Talanta. 2021 Feb 1;223(Pt 2):121748. doi: 10.1016/j.talanta.2020.121748.

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