Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003289)
Formula
SVG example
Reactant Valdecoxib metabolite M2 Product Valdecoxib metabolite M7
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003301 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Valdecoxib [1], [2]
MR003480 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Parecoxib [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003290 Valdecoxib metabolite M2 Valdecoxib metabolite M2-G Unclear Valdecoxib [2]
MR003288 Valdecoxib metabolite M2 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Valdecoxib [2]
MR003494 Valdecoxib metabolite M2 Valdecoxib metabolite M2-G Conjugation - Glucuronidation Parecoxib [1], [2]
MR003481 Valdecoxib metabolite M2 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Parecoxib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003292 Valdecoxib metabolite M7 Valdecoxib metabolite M8 Oxidation - S-Oxidation Valdecoxib [1]
MR003484 Valdecoxib metabolite M7 Valdecoxib metabolite M8 Oxidation - S-Oxidation Parecoxib [1]
References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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