Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003518)
Formula Reactant Endoxifen Product 4-hydroxytamoxifen sulfate
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase 1A1 (SULT1A1) DME Info
Sulfotransferase 1E1 (SULT1E1) DME Info
Metabolic Type Conjugation - Sulfation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011558 Endoxifen Endoxifen O-Glucuronide Unclear - Unclear Endoxifen [1]
MR011559 Endoxifen Endoxifen Sulfate Unclear - Unclear Endoxifen [1]
MR011557 Endoxifen Norendoxifen Oxidation - Demethylation Endoxifen [1]
MR003519 Endoxifen 4-endoxifen sulfate Conjugation - Sulfation Tamoxifen citrate [2]
MR003517 Endoxifen Norendoxifen Oxidation - Demethylation Tamoxifen citrate [2]
MR003520 Endoxifen Tamoxifen glucuronides Conjugation - Glucuronidation Tamoxifen citrate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003528 4-hydroxytamoxifen 4-hydroxytamoxifen sulfate Conjugation - Sulfation Tamoxifen citrate [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003529 4-hydroxytamoxifen sulfate Endoxifen Conjugation - Sulfation Tamoxifen citrate [2]
References
1 Clinical pharmacokinetics and pharmacogenetics of tamoxifen and endoxifen
2 PharmGKB:Tamoxifen citrate

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