Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004576)
Formula
SVG example
Oxidationn
Reactant Itopride Product Itopride N-oxide
Reactant Info Product Info
Metabolic Enzyme Dimethylaniline oxidase 3 (FMO3) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003658 HSR-803 Itopride N-oxide Oxidation - N-oxidation HSR-803 [1], [2]
References
1 The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. Drug Metab Dispos. 2000 Oct;28(10):1231-7.
2 Effect of two-linked mutations of the FMO3 gene on itopride metabolism in Chinese healthy volunteers. Eur J Clin Pharmacol. 2014 Nov;70(11):1333-8.

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