Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004743)
Formula
	Reactant	4-hydroxymidazolam	Product	1',4'-dihydroxymidazolam
	Reactant	Reactant Info	Product	Product Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR004742	Midazolam hydrochloride	4-hydroxymidazolam	Oxidation - 4-hydroxylation	Midazolam hydrochloride	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR004747	Midazolam hydrochloride	1',4'-dihydroxymidazolam	Unclear	Midazolam hydrochloride	[2]

References
1	Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions
2	Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

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